HCID 178453764, compound → HCID 178453765, compound

HRID 269686Notes

Reaction equation

HRID 269686 reaction equation
[C:1]([O:5][C:6]([N:8]([C:16](=[NH:48])[NH:17][CH2:18][CH2:19][CH2:20][C@H:21]([NH:37]C(OCC1C=CC=CC=1)=O)[C:22](=[O:36])[NH:23][CH2:24][CH:25]([OH:35])[CH2:26][NH:27][C:28](=[O:34])[O:29][C:30]([CH3:33])([CH3:32])[CH3:31])[C:9]([O:11][C:12]([CH3:15])([CH3:14])[CH3:13])=[O:10])=[O:7])([CH3:4])([CH3:3])[CH3:2]>[Pd].C(O)C>[C:12]([O:11][C:9]([N:8]([C:16](=[NH:48])[NH:17][CH2:18][CH2:19][CH2:20][C@@H:21]([C:22]([NH:23][CH2:24][CH:25]([OH:35])[CH2:26][NH:27][C:28]([O:29][C:30]([CH3:33])([CH3:32])[CH3:31])=[O:34])=[O:36])[NH2:37])[C:6]([O:5][C:1]([CH3:2])([CH3:4])[CH3:3])=[O:7])=[O:10])([CH3:13])([CH3:14])[CH3:15]

Participants

4

Reactant 1

HCID 178453764HCID 178453764, compound

Product 1

HCID 178453765HCID 178453765, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

28 mg of palladium on activated carbon (10%) are added to a mixture of 0.182 g (0.27 mmol) of the compound from Example 256A in 10 ml of ethanol, and the mixture is then hydrogenated under atmospheric pressure for 12 h. The reaction mixture is filtered through kieselguhr, and the filtrate is concentrated in vacuo and dried under high vacuum. The crude product is reacted without further purification.

Workup

  1. filtrationThe reaction mixture is filtered through kieselguhr
  2. concentrationthe filtrate is concentrated in vacuo
  3. customdried under high vacuum
  4. customThe crude product is reacted without further purification

Sources & evidence

ORD record
ord-ba0403d426854403baea807e2ebdda65
Source dataset
uspto-grants-2008_11
Patent number
US07446102B2

Reaction notes

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