HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → Benzyl((4S)-5-[(3-amino-2-hydroxypropyl)amino]-4-{[(benzyloxy)carbonyl]amino}-5-oxopentyl)carbamate hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Benzyl {(1S)-4-{[(benzyloxy)carbonyl]amino}-1-[({3-[(tert-butoxycarbonyl)amino]-2-hydroxypropyl}amino)carbonyl]butyl}carbamate | HCID 86625290 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | Benzyl((4S)-5-[(3-amino-2-hydroxypropyl)amino]-4-{[(benzyloxy)carbonyl]amino}-5-oxopentyl)carbamate hydrochloride | HCID 69219437 | — |
Reaction Steps
6.8 ml of a 4N solution of hydrogen chloride in dioxane are added to a solution of 0.263 g (0.46 mmol) of the compound from Example 258A in 1 ml of dioxane at 0° C. After 2 h at RT, the reaction solution is concentrated in vacuo and coevaporated with dichloromethane several times. The remaining solid is dried to constant weight under high vacuum.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07446102B2 |
| Source dataset | uspto-grants-2008_11 |
| ORD ID | ord-3d01529a49944a54b455c638c2d93029 |
| Source note | uspto-grants-2008_11 |