HCID 86624523, compound → HCID 86624524, compound

HRID 269690Notes

Reaction equation

HRID 269690 reaction equation
C(OC(=O)[NH:10][CH2:11][C@H:12]([NH:26][C:27]([O:29][C:30]([CH3:33])([CH3:32])[CH3:31])=[O:28])[C:13]([NH:15][CH2:16][CH2:17][NH:18][C:19]([O:21][C:22]([CH3:25])([CH3:24])[CH3:23])=[O:20])=[O:14])C1C=CC=CC=1>[Pd].C(O)(=O)C.C(O)C.O>[NH2:10][CH2:11][C@@H:12]([C:13]([NH:15][CH2:16][CH2:17][NH:18][C:19]([O:21][C:22]([CH3:25])([CH3:24])[CH3:23])=[O:20])=[O:14])[NH:26][C:27]([O:29][C:30]([CH3:31])([CH3:32])[CH3:33])=[O:28]

Participants

4

Reactant 1

HCID 86624523HCID 86624523, compound

Product 1

HCID 86624524HCID 86624524, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 86584229Acetic acid ethanol waterSolvent

Procedure

50 mg of palladium on activated carbon (10%) are added to a mixture of 0.41 g (0.847 mmol) of the compound from Example 260A in 80 ml of acetic acid/ethanol/water (4:1:1), and the mixture is then hydrogenated under atmospheric pressure for 12 h. The reaction mixture is filtered through kieselguhr, and the filtrate is concentrated in vacuo and dried under high vacuum. The crude product is reacted without further purification.

Workup

  1. filtrationThe reaction mixture is filtered through kieselguhr
  2. concentrationthe filtrate is concentrated in vacuo
  3. customdried under high vacuum
  4. customThe crude product is reacted without further purification

Sources & evidence

ORD record
ord-c527f1d8356c45059f3c1a3f0bfc498b
Source dataset
uspto-grants-2008_11
Patent number
US07446102B2

Reaction notes

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