HCID 88986879, compound → HCID 50940293, compound

Participants

Reaction Steps

29.7 mg (0.029 mmol) of tert-butyl(2-{[(2S)-5-[(tert-butoxycarbonyl)amino]-2-({[(8S,11S,14S)-14-[(tert-butoxycarbonyl)amino]-11-{3-[(tert-butoxycarbonyl)amino]propyl}-5,17-dihydroxy-10,13-dioxo-9,12-diazatricyclo[14.3.1.12,6]henicosa-1(20),2(21),3,5,16,18-hexaen-8-yl]carbonyl}amino)pentanoyl]amino}ethyl)carbamate (Example 167A) are dissolved in 3.0 ml of 4N hydrogen chloride in dioxane and stirred at room temperature for 2 h. The solvent is evaporated in vacuo and the remaining solid is converted by preparative HPLC (Reprosil ODS-A, mobile phase acetonitrile/0.2% aqueous trifluoroacetic acid 5:95→95:5) into the tetra(hydrotrifluoroacetate).

Provenance & Evidence