HRID269698

反应详情

EQUATION

反应方程式

REACTANTS

反应物

反应SMILES：CC(C)(C)OC(=O)NCCC[C@@H]1NC(=O)[C@@H](NC(=O)OC(C)(C)C)Cc2cc(ccc2O)-c2ccc(O)c(c2)C[C@@H](C(=O)NCCC[C@H](N)CC(=O)NCCN)NC1=O

HCID70806691

未命名化合物

HCID86639075

未命名化合物

HCID178418361

未命名化合物

PRODUCTS

产物

反应SMILES：Cl.Cl.Cl.Cl.NCCC[C@@H]1NC(=O)[C@@H](N)Cc2cc(ccc2O)-c2ccc(O)c(c2)C[C@@H](C(=O)NCCC[C@H](N)CC(=O)NCCN)NC1=O

HCID50940432

未命名化合物

PROCEDURE

实验过程

8 mg (0.010 mmol) of tert-butyl{3-[(8S,11S,14S)-8-[({(4S)-4-amino-6-[(2-aminoethyl)amino]-6-oxohexyl}amino)carbonyl]-14-[(tert-butoxycarbonyl)amino]-5,17-dihydroxy-10,13-dioxo-9,12-diazatricyclo[14.3.1.12,6]henicosa-1(20),2(21),3,5,16,18-hexaen-11-yl]propyl}carbamate bis(hydroacetate) (Example 206A) are added into 0.4 ml of a 4N solution of hydrogen in dioxane chloride and stirred at RT for 30 min. The reaction solution is concentrated, coevaporated with dichloromethane several times and dried under high vacuum.

WORKUP

后处理

concentrationThe reaction solution is concentrated
customdried under high vacuum

来源与证据

来源类型: Open Reaction Database
ORD记录: ord-60ddf54e60194abcafe22e38acbdf872
来源数据集: uspto-grants-2008_11
DOI: 10.6084/m9.figshare.5104873.v1
专利号: US07446102B2
来源说明: uspto-grants-2008_11

反应SMILES

C(OC(=O)[NH:7][CH2:8][CH2:9][CH2:10][C@@H:11]1[NH:29][C:28](=[O:30])[C@@H:27]([NH:31]C(OC(C)(C)C)=O)[CH2:26][C:25]2[CH:39]=[C:21]([CH:22]=[CH:23][C:24]=2[OH:40])[C:20]2=[CH:41][C:16](=[C:17]([OH:42])[CH:18]=[CH:19]2)[CH2:15][C@@H:14]([C:43]([NH:45][CH2:46][CH2:47][CH2:48][C@H:49]([NH2:57])[CH2:50][C:51]([NH:53][CH2:54][CH2:55][NH2:56])=[O:52])=[O:44])[NH:13][C:12]1=[O:58])(C)(C)C.[H][H].[Cl-:62].O1CCOCC1>>[ClH:62].[ClH:62].[ClH:62].[ClH:62].[NH2:31][C@H:27]1[CH2:26][C:25]2[CH:39]=[C:21]([CH:22]=[CH:23][C:24]=2[OH:40])[C:20]2=[CH:41][C:16](=[C:17]([OH:42])[CH:18]=[CH:19]2)[CH2:15][C@@H:14]([C:43]([NH:45][CH2:46][CH2:47][CH2:48][C@H:49]([NH2:57])[CH2:50][C:51]([NH:53][CH2:54][CH2:55][NH2:56])=[O:52])=[O:44])[NH:13][C:12](=[O:58])[C@H:11]([CH2:10][CH2:9][CH2:8][NH2:7])[NH:29][C:28]1=[O:30]