HCID 70806691, compound → HCID 50940432, compound

HRID 269698Notes

Reaction equation

HRID 269698 reaction equation
C(OC(=O)[NH:7][CH2:8][CH2:9][CH2:10][C@@H:11]1[NH:29][C:28](=[O:30])[C@@H:27]([NH:31]C(OC(C)(C)C)=O)[CH2:26][C:25]2[CH:39]=[C:21]([CH:22]=[CH:23][C:24]=2[OH:40])[C:20]2=[CH:41][C:16](=[C:17]([OH:42])[CH:18]=[CH:19]2)[CH2:15][C@@H:14]([C:43]([NH:45][CH2:46][CH2:47][CH2:48][C@H:49]([NH2:57])[CH2:50][C:51]([NH:53][CH2:54][CH2:55][NH2:56])=[O:52])=[O:44])[NH:13][C:12]1=[O:58])(C)(C)C.[H][H].[Cl-:62].O1CCOCC1>>[ClH:62].[ClH:62].[ClH:62].[ClH:62].[NH2:31][C@H:27]1[CH2:26][C:25]2[CH:39]=[C:21]([CH:22]=[CH:23][C:24]=2[OH:40])[C:20]2=[CH:41][C:16](=[C:17]([OH:42])[CH:18]=[CH:19]2)[CH2:15][C@@H:14]([C:43]([NH:45][CH2:46][CH2:47][CH2:48][C@H:49]([NH2:57])[CH2:50][C:51]([NH:53][CH2:54][CH2:55][NH2:56])=[O:52])=[O:44])[NH:13][C:12](=[O:58])[C@H:11]([CH2:10][CH2:9][CH2:8][NH2:7])[NH:29][C:28]1=[O:30]

Participants

4

Reactant 3

HCID 70806691HCID 70806691, compoundHCID 86639075HCID 86639075, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 50940432HCID 50940432, compound

Procedure

8 mg (0.010 mmol) of tert-butyl{3-[(8S,11S,14S)-8-[({(4S)-4-amino-6-[(2-aminoethyl)amino]-6-oxohexyl}amino)carbonyl]-14-[(tert-butoxycarbonyl)amino]-5,17-dihydroxy-10,13-dioxo-9,12-diazatricyclo[14.3.1.12,6]henicosa-1(20),2(21),3,5,16,18-hexaen-11-yl]propyl}carbamate bis(hydroacetate) (Example 206A) are added into 0.4 ml of a 4N solution of hydrogen in dioxane chloride and stirred at RT for 30 min. The reaction solution is concentrated, coevaporated with dichloromethane several times and dried under high vacuum.

Workup

  1. concentrationThe reaction solution is concentrated
  2. customdried under high vacuum

Sources & evidence

ORD record
ord-60ddf54e60194abcafe22e38acbdf872
Source dataset
uspto-grants-2008_11
Patent number
US07446102B2

Reaction notes

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