Water → HCID 69216629, compound

Participants

Reaction Conditions

Reaction Steps

To 37 mL of water were added 7.49 g (23.9 mmol) of methyl (±)-3-benzylamino-3-(3,4-methylenedioxyphenyl)propionate and 1.00 g (12.0 mmol) of sodium hydrogen carbonate, and the mixture was maintained at 30° C. To the resulting mixture was added 37.5 mg of lipase (CAL; available from Roche, CHIRAZYME L-2 (trade name)) originated from Candida antarctica at the same temperature, and the mixture was reacted at 30° C. while stirring. After 24 hours, at the time when the conversion rate of the starting materials reached 29.1%, 40 ml of toluene was added to the reaction mixture. After the resulting mixture was stirred for 15 minutes at room temperature, the mixture was filtered and dried to obtain 1.52 g (Isolated yield based on methyl (±)-3-benzylamino-3-(4-fluorophenyl)propionate=21.2%) of 3-(R) or (S)-benzylamino-3-(3,4-methylenedioxyphenyl)propionic acid as white crystal.

Provenance & Evidence