4-Methoxy-7-morpholinobenzo[d]thiazol-2-amine → HCID 178492015, compound

HRID 269740Notes

Reaction equation

HRID 269740 reaction equation
[CH3:1][O:2][C:3]1[C:8]2[N:9]=[C:10]([NH2:12])[S:11][C:7]=2[C:6]([N:13]2[CH2:18][CH2:17][O:16][CH2:15][CH2:14]2)=[CH:5][CH:4]=1.Cl[C:20]([CH2:22][C@@H:23]1[CH2:28][CH2:27][C@H:26]([O:29]C(=O)C)[CH2:25][CH2:24]1)=[O:21].C(O[C@@H]1CC[C@H](CC(NC2SC3C(N4CCOCC4)=CC=C(OC)C=3N=2)=O)C1)(=O)C>>[OH:29][C@@H:26]1[CH2:27][CH2:28][C@H:23]([CH2:22][C:20]([NH:12][C:10]2[S:11][C:7]3[C:6]([N:13]4[CH2:18][CH2:17][O:16][CH2:15][CH2:14]4)=[CH:5][CH:4]=[C:3]([O:2][CH3:1])[C:8]=3[N:9]=2)=[O:21])[CH2:24][CH2:25]1

Participants

4

Reactant 3

HCID 114028614-Methoxy-7-morpholinobenzo[d]thiazol-2-amineHCID 86602720HCID 86602720, compoundHCID 178476594HCID 178476594, compound

Product 1

HCID 178492015HCID 178492015, compoundYield 33%

Procedure

Using 4-methoxy-7-morpholin-4-yl-benzothiazol-2-ylamine and (cis)-acetic acid 4-chlorocarbonylmethyl-cyclohexyl ester, the tide compound was synthesized in exact the same manner as (cis)-2-(3-acetoxy-cyclopentyl)-N-(4-methoxy-7-morpholin-4-yl-benzothiazol-2-yl)-acetamide and obtained as light yellow crystals (33% yield). MS: m/e=406(M+H+), mp 212-216° C.

Sources & evidence

ORD record
ord-66096c2542e04cb5be03e4678aa778fb
Source dataset
uspto-grants-2008_11
Patent number
US07449461B2

Reaction notes

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