4-Methoxy-7-morpholinobenzo[d]thiazol-2-amine → HCID 178492016, compound

HRID 269741Notes

Reaction equation

HRID 269741 reaction equation
COC1C2N=C(N)SC=2C(N2CCOCC2)=CC=1.ClC(C[C@H]1CC[C@H](OC(=O)C)CC1)=O.[OH:33][C@@H:34]1[CH2:39][CH2:38][C@H:37]([CH2:40][C:41]([NH:43][C:44]2[S:45][C:46]3[C:52]([N:53]4[CH2:58][CH2:57][O:56][CH2:55][CH2:54]4)=[CH:51][CH:50]=[C:49]([O:59][CH3:60])[C:47]=3[N:48]=2)=[O:42])[CH2:36][CH2:35]1>>[OH:33][C@H:34]1[CH2:35][CH2:36][C@H:37]([CH2:40][C:41]([NH:43][C:44]2[S:45][C:46]3[C:52]([N:53]4[CH2:58][CH2:57][O:56][CH2:55][CH2:54]4)=[CH:51][CH:50]=[C:49]([O:59][CH3:60])[C:47]=3[N:48]=2)=[O:42])[CH2:38][CH2:39]1

Participants

4

Reactant 3

HCID 114028614-Methoxy-7-morpholinobenzo[d]thiazol-2-amineHCID 178476595HCID 178476595, compoundHCID 178492015HCID 178492015, compound

Product 1

HCID 178492016HCID 178492016, compound

Procedure

Using 4-methoxy-7-morpholin-4-yl-benzothiazol-2-ylamine and (trans)-acetic acid 4-chlorocarbonylmethyl-cyclohexyl ester, the title compound was synthesized in exact the same manner as described for (cis)-2-(4-Hydroxy-cyclohexyl)-N-(4-methoxy-7-morpholin-4-yl-benzothiazol-2-yl)-acetamide and obtained as light yellow crystals (51% yield). MS: m/e=406(M+H+), mp 190-192° C.

Sources & evidence

ORD record
ord-1501f9622b814306bfedc102962e33a1
Source dataset
uspto-grants-2008_11
Patent number
US07449461B2

Reaction notes

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