HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyridinium chloride → 7-Fluoro-6-methoxy-4-[4-(pyridin-2-ylsulfanyl)-phenylamino]quinoline-3-carbonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyridinium chloride | HCID 10176127 | — |
| Reactant | 4-Chloro-7-fluoro-6-methoxy-3-quinolinecarbonitrile | HCID 12150703 | — |
| Reactant | 4-[(Pyridin-2-yl)sulfanyl]aniline | HCID 18971660 | — |
| Solvent | Glycol monoethyl ether | HCID 8076 | — |
| Product | 7-Fluoro-6-methoxy-4-[4-(pyridin-2-ylsulfanyl)-phenylamino]quinoline-3-carbonitrile | HCID 68461455 | 77% |
Reaction Steps
Following the procedure of Example 1, a mixture of 635.4 mg (2.68 mmol) 4-chloro-7-fluoro-6-methoxy-quinoline-3-carbonitrile, 542.1 mg (2.81 mmol) of 4-(pyridin-2-ylsulfanyl)phenylamine and 309.8 mg (2.68 mmol) of pyridine hydrochloride are refluxed in 2-ethoxyethanol (27 mL) at 100° C. for 12 hours to provide 830 mg of 7-fluoro-6-methoxy-4-[4-(pyridin-2-ylsulfanyl)-phenylamino]quinoline-3-carbonitrile as an off-white solid, mp 231-233° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07449460B2 |
| Source dataset | uspto-grants-2008_11 |
| ORD ID | ord-c0155db10205463c8513de4306c8e379 |
| Source note | uspto-grants-2008_11 |