Iodoethane → HCID 59833620, compound

Participants

Reaction Conditions

Reaction Steps

To a mixture of the nitro derivative, 6-methyl-5-nitro-3-propyl-1,3-dihydropyrimidine-2,4-dione prepared in Example 5 (1.56 g) and K2CO3 (3.0 g) in DMF was added iodoethane. The reaction mixture was heated at 80° C. for 3 h. After completion of the starting material, K2CO3 was filtered and DMF was distilled off. The residue was dissolved in ethyl acetate, washed with water, brine and dried over Na2SO4 Removal of solvent furnished the product as yellow oil, which was purified using flash chromatography. Elution with 30% ethyl acetate/hexane furnished the material as white solid, which was characterized by using NMR and mass.

Provenance & Evidence