反应详情

温度

0 °C

1.2 g, 6 mmol, of 6-methyl-1,3-dipropyl-1,3-dihydropyrimidine-2,4-dione, as prepared in Example 1, was added in small portions to a cooled (0° C.) solution of concentrated sulfuric acid (3.0 ml) and nitric acid (2.0 ml). The reaction stirred at 0° C. for 2 hours. The reaction mixture was poured over ice and a green amorphous solid formed. The solid was removed by filtration and washed copiously with water. The solid was dissolved in dichloromethane and concentrated. The residue was purified using column chromatography (1:1.2 EtOAc:Hexanes) to yield 6-methyl-5-nitro-1,3-dipropyl-1,3-dihydropyrimidine-2,4-dione(0.430 g, HNMR)

1. additionwas added in small portions to
2. additionThe reaction mixture was poured over ice
3. customa green amorphous solid formed
4. customThe solid was removed by filtration
5. washwashed copiously with water
6. dissolutionThe solid was dissolved in dichloromethane
7. concentrationconcentrated
8. customThe residue was purified