Hydrochloric Acid → HCID 11326776, compound

Participants

Reaction Steps

To a solution of 6-{(1E)-2-[1-benzylpyrazol-4-yl]vinyl}-5-nitro-1,3-dipropyl-1,3-dihydropyrimidine-2,4-dione prepared in Example 18 (0.24 g, 0.57 mmol) in N,N′-dimethyl formamide (4 ml) was added tin (II) chloride (1.07 g, 5.7 mmol). The reaction mixture was heated to 150° for 2 hours. After cooling to room temperature 2N HCl (6 ml) was added and a light brown precipitate formed and was removed by filtration and washed with water (5 ml). The precipitate (0,025 g) was dissolved in DMSO (0.5 ml) and purified using preparative HPLC to yield 6-[1-benzylpyrazol-4-yl]-1,3-dipropyl-1,3-dihydropyrrolo[3,2-d]pyrimidine-2,4-dione, (0.009 g, M+1=392.2)

Provenance & Evidence