HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → 1-(4-Aminophenyl)pyrrolidine-3-carbonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Sodium Cyanide | HCID 8929 | — |
| Reactant | Methanesulfonyl chloride | HCID 31297 | — |
| Reactant | 1-(4-Nitrophenyl)pyrrolidin-3-ol | HCID 12067813 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Solvent | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Product | 1-(4-Aminophenyl)pyrrolidine-3-carbonitrile | HCID 23071573 | — |
Reaction Steps
1-(4-Nitrophenyl)pyrroidin-3-ol and methanesulfonyl chloride were allowed to undergo the reaction in THF in the presence of triethylamine. The resulting compound and sodium cyanide were allowed to undergo the reaction in 1-methyl-2-pyrrolidone under heating. The resulting compound was subjected to catalytic hydrogenation in the same manner as shown in Reference Example 3 to obtain 1-(4-aminophenyl)pyrrolidine-3-carbonitrile. NMR2: 1.48 (9H, s), 3.12-3.19 (2H, m), 6.46-6.50 (2H, m).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07449456B2 |
| Source dataset | uspto-grants-2008_11 |
| ORD ID | ord-98c69f1e9ab74029a06815905f64a435 |
| Source note | uspto-grants-2008_11 |