Morpholine → HCID 66584384, compound

Participants

Reaction Steps

2-[1-(4-Nitrophenyl)piperidin-4-yl]ethanol and methanesulfonyl chloride were allowed to undergo the reaction in THF in the presence of triethylamine. The resulting compound and morpholine were allowed to undergo the reaction under heating in 1-methyl-2-pyrrolidine. The resulting compound was subjected to catalytic hydrogenation in the same manner as shown in Reference Example 3 to obtain 4-[4-(2-morpholin-4-ylethyl)piperidin-1-yl]aniline. NMR2 (CDCl3): 3.21-3.45 (4H, m), 3.71-3.80 (4H, m) 6.63-6.66 (2H, m).

Provenance & Evidence