HuagongsheHuagongshe Chemistry Print Report · For research reference only
p-Fluoronitrobenzene → 4-(4-Aminophenyl)morpholine-3-carboxylic acid ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | p-Fluoronitrobenzene | HCID 9590 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | Ethyl morpholine-3-carboxylate | HCID 18354446 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | 4-(4-Aminophenyl)morpholine-3-carboxylic acid ethyl ester | HCID 67388654 | — |
Reaction Steps
4-Fluoronitrobenzene and morpholine-3-carboxylic acid ethyl ester were allowed to undergo the reaction at 100° C. in DMSO in the presence of diisopropylethylamine, and then the resulting compound was subjected to catalytic hydrogenation in the same manner as shown in Reference Example 3 to obtain 4-(4-aminophenyl)morpholine-3-carboxylic acid ethyl ester. ESI: 251.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07449456B2 |
| Source dataset | uspto-grants-2008_11 |
| ORD ID | ord-0cfbcea417354ee5ab462f01c3297e66 |
| Source note | uspto-grants-2008_11 |