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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 269822Generated: October 31, 2026

Dimethyl Sulfate → [3-(Aminomethyl)-4-fluorophenyl]methanol

https://huagongshe.com/reaction/269822

Reaction equation

Participants

RoleNameHCIDCharge
ReactantDimethyl SulfateHCID 6497—
Reactant2-Fluoro-5-formylbenzonitrileHCID 2769582—
ReactantSodium borohydrideHCID 4311764—
SolventTetrahydrofuranHCID 8028—
Product[3-(Aminomethyl)-4-fluorophenyl]methanolHCID 23071542—

Reaction Steps

2-Fluoro-5-formylbenzonitrile was treated with sodium borohydride and dimethyl sulfate in THF to obtain 5-hydroxymethyl-2-fluorobenzylamine. F: 156.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07449456B2
Source datasetuspto-grants-2008_11
ORD IDord-8ac83216b98d4c7e868fe368a7924c7f
Source noteuspto-grants-2008_11