HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Nitrobenzenesulfonyl chloride → tert-Butyl 4-(4-aminophenylsulfonyl)piperazine-1-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Nitrobenzenesulfonyl chloride | HCID 7404 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | tert-Butyl piperazine-1-carboxylate | HCID 143452 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | tert-Butyl 4-(4-aminophenylsulfonyl)piperazine-1-carboxylate | HCID 10617209 | — |
Reaction Steps
1-Boc-piperazine and 4-nitrobenzenesulfonyl chloride were allowed to undergo the reaction in DMF in the presence of triethylamine, and then the nitro group was reduced in the sama manner as the catalytic hydrogenation shown in Reference Example 3 to obtain tert-butyl 4-[(4-aminophenyl)sulfonyl]piperazine-1-carboxylate. FN: 340.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07449456B2 |
| Source dataset | uspto-grants-2008_11 |
| ORD ID | ord-45995bc4de344d358313b90180261fa9 |
| Source note | uspto-grants-2008_11 |