1-(4-Methoxy-3-methylphenyl)-4-phenethylpiperazine → HCID 23111418, compound

HRID 269876Notes

Reaction equation

HRID 269876 reaction equation
COC1C=CC(N2CCN(CCC3C=CC=CC=3)CC2)=CC=1C.C[O:25][C:26]1[CH:27]=[CH:28][C:29]([N:34]2[CH2:39][CH2:38][N:37]([CH2:40][CH2:41][C:42]3[CH:47]=[CH:46][CH:45]=[CH:44][CH:43]=3)[CH2:36][CH2:35]2)=[C:30]([CH:33]=1)[C:31]#[N:32]>>[OH:25][C:26]1[CH:27]=[CH:28][C:29]([N:34]2[CH2:39][CH2:38][N:37]([CH2:40][CH2:41][C:42]3[CH:43]=[CH:44][CH:45]=[CH:46][CH:47]=3)[CH2:36][CH2:35]2)=[C:30]([CH:33]=1)[C:31]#[N:32]

Participants

3

Reactant 2

HCID 231115101-(4-Methoxy-3-methylphenyl)-4-phenethylpiperazineHCID 23111514HCID 23111514, compound

Product 1

HCID 23111418HCID 23111418, compoundYield 50.5%

Procedure

Production Example 10 was repeated except that 1-(4-methoxy-3-methylphenyl)-4-phenethylpiperazine was replaced with 5-methoxy-2-(4-phenethylpiperazin-1-yl)benzonitrile (257 mg), and the resulting crude product was purified on TLC (developer, chloroform: methanol=12:1) to provide 5-hydroxy-2-(4-phenethyl-piperazin-1-yl)benzonitrile (124 mg).

Workup

  1. customthe resulting crude product was purified on TLC (developer, chloroform: methanol=12:1)

Sources & evidence

ORD record
ord-bf92932be13245cebf51a63a5faa050f
Source dataset
uspto-grants-2008_11
Patent number
US07449466B2

Reaction notes

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