HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Phenethylpiperazine → 1-(4-Benzyloxy-3-chlorophenyl)-4-(3-cyclohexylpropyl)piperazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Phenethylpiperazine | HCID 79214 | — |
| Reactant | 4-Bromo-1-methoxy-2-methylbenzene | HCID 608315 | — |
| Reactant | 1-(3-Cyclohexylpropyl)piperazine | HCID 2737393 | — |
| Reactant | 1-Benzyloxy-4-bromo-2-chlorobenzene | HCID 10913524 | — |
| Product | 1-(4-Benzyloxy-3-chlorophenyl)-4-(3-cyclohexylpropyl)piperazine | HCID 23111408 | 100.4% |
Reaction Steps
Production Example 9 was repeated except that 5-bromo-2-methoxytoluene was replaced with 1-benzyloxy-4-bromo-2-chlorobenzene (861 mg), and l-phenethylpiperazine was replaced with 1-(3-cyclohexylpropyl)piperazine (730 mg). Whereby obtained crude product was purified on silica gel column chromatography (eluent, chloroform: methanol=10:1) to provide 1-(4-benzyloxy-3-chlorophenyl)-4-(3-cyclohexylpropyl)piperazine (1.24 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07449466B2 |
| Source dataset | uspto-grants-2008_11 |
| ORD ID | ord-710a741b900940cbb5069251e283564b |
| Source note | uspto-grants-2008_11 |