Phenethyl bromide → HCID 23111502, compound

HRID 269890Notes

Reaction equation

HRID 269890 reaction equation
Cl.Cl.COC1C=CC(N2CCNCC2)=CC=1.Br[CH2:18][CH2:19][C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1.[F:26][C:27]1[CH:28]=[C:29]([N:35]2[CH2:40][CH2:39][NH:38][CH2:37][CH2:36]2)[CH:30]=[CH:31][C:32]=1[O:33][CH3:34].C1(CCBr)CCCCC1>>[CH:20]1([CH2:19][CH2:18][N:38]2[CH2:37][CH2:36][N:35]([C:29]3[CH:30]=[CH:31][C:32]([O:33][CH3:34])=[C:27]([F:26])[CH:28]=3)[CH2:40][CH2:39]2)[CH2:25][CH2:24][CH2:23][CH2:22][CH2:21]1

Participants

5

Reactant 4

HCID 7666Phenethyl bromideHCID 15440(2-Bromoethyl)cyclohexaneHCID 27237001-(4-Methoxyphenyl)-piperazine, dihydrochlorideHCID 4738807HCID 4738807, compound

Product 1

HCID 23111502HCID 23111502, compound

Procedure

Production Example 1 was repeated except that 1-(4-methoxyphenyl)piperazine dihydrochloride and (2-bromoethyl)-benzene were replaced with 1-(3-fluoro-4-methoxyphenyl)piperazine (456 mg) and 2-cyclohexylethyl bromide (377 μL), respectively. Thus obtained crude product was purified on silica gel column chromatography (eluent, chloroform: methanol=30:1) to provide 1-(2-cyclohexylethyl)-4-(3-fluoro-4-methoxyphenyl)piperazine (229 mg).

Workup

  1. customThus obtained crude product
  2. customwas purified on silica gel column chromatography (eluent, chloroform: methanol=30:1)

Sources & evidence

ORD record
ord-1a89300da9614fea90c7180323557e88
Source dataset
uspto-grants-2008_11
Patent number
US07449466B2

Reaction notes

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