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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 269893Generated: October 25, 2026

1-(4-Benzyloxy-3-chlorophenyl)-4-(3-cyclohexylpropyl)piperazine → 4-[4-[2-(4-Chlorophenyl)-ethyl]piperazin-1-yl]-2-fluorophenol

https://huagongshe.com/reaction/269893

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-(4-Benzyloxy-3-chlorophenyl)-4-(3-cyclohexylpropyl)piperazineHCID 23111408—
Reactant1-(4-Benzyloxy-3-fluorophenyl)-4-[2-(4-chlorophenyl)-ethyl]piperazineHCID 23111471—
Product4-[4-[2-(4-Chlorophenyl)-ethyl]piperazin-1-yl]-2-fluorophenolHCID 2311143487.4%

Reaction Steps

Production Example 30 was repeated except that 1-(4-benzyloxy-3-chlorophenyl)-4-(3-cyclohexylpropyl)piperazine was replaced with 1-(4-benzyloxy-3-fluorophenyl)-4-[2-(4-chlorophenyl)-ethyl]piperazine (373 mg), to provide crude 4-[4-[2-(4-chlorophenyl)-ethyl]piperazin-1-yl]-2-fluorophenol (257 mg).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07449466B2
Source datasetuspto-grants-2008_11
ORD IDord-6ac0f3d567ea451eb9b2e034474502fb
Source noteuspto-grants-2008_11