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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 269896Generated: October 25, 2026

1-Phenethylpiperazine → 1-(4-Benzyloxy-3-fluorophenyl)-4-(3-cyclohexylpropyl)piperazine

https://huagongshe.com/reaction/269896

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-PhenethylpiperazineHCID 79214—
Reactant4-Bromo-1-methoxy-2-methylbenzeneHCID 608315—
Reactant1-(3-Cyclohexylpropyl)piperazineHCID 2737393—
Reactant1-(Benzyloxy)-4-bromo-2-fluorobenzeneHCID 18757491—
Product1-(4-Benzyloxy-3-fluorophenyl)-4-(3-cyclohexylpropyl)piperazineHCID 23111415111.4%

Reaction Steps

Production Example 9 was repeated except that 5-bromo-2-methoxytoluene and 1-(2-phenylethyl)piperazine were replaced with 1-benzyloxy-4-bromo-2-fluorobenzene (1.42 g) and 1-(3-cyclo-hexylpropyl)piperazine (1.28 g), respectively, to provide crude 1-(4-benzyloxy-3-fluorophenyl)-4-(3-cyclohexylpropyl)piperazine (2.31 g).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07449466B2
Source datasetuspto-grants-2008_11
ORD IDord-c63e18e059fe474497463d85a52780e9
Source noteuspto-grants-2008_11