HuagongsheHuagongshe Chemistry Print Report · For research reference only
Piperazine → 1-(4-Benzyloxy-3-fluorophenyl)piperazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Piperazine | HCID 4837 | — |
| Reactant | 4-Bromo-1-methoxy-2-methylbenzene | HCID 608315 | — |
| Reactant | 1-(Benzyloxy)-4-bromo-2-fluorobenzene | HCID 18757491 | — |
| Product | 1-(4-Benzyloxy-3-fluorophenyl)piperazine | HCID 23111483 | 54.1% |
Reaction Steps
Production Example 9 was repeated except that 5-bromo-2-methoxytoluene and 1-(2-phenethyl)piperazine were replaced with 1-benzyloxy-4-bromo-2-fluorobenzene (6.742 g) and piperazine (12.404 g), respectively. The resulting crude product was purified on silica gel column chromatography (eluent, chloroform: methanol=2:1) to provide 1-(4-benzyloxy-3-fluorophenyl)piperazine (3.716 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07449466B2 |
| Source dataset | uspto-grants-2008_11 |
| ORD ID | ord-85b653a234ca4a8f98ef32221a83778e |
| Source note | uspto-grants-2008_11 |