Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1-(4-Benzyloxy-3-chlorophenyl)-4-(3-cyclohexylpropyl)piperazine → 2-Fluoro-4-[4-(3-phenylpropyl)piperazin-1-yl]phenol
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1-(4-Benzyloxy-3-chlorophenyl)-4-(3-cyclohexylpropyl)piperazine | HCID 23111408 | — |
| 반응물 | 1-(4-Benzyloxy-3-fluorophenyl)-4-(3-phenylpropyl)-piperazine | HCID 23111437 | — |
| 생성물 | 2-Fluoro-4-[4-(3-phenylpropyl)piperazin-1-yl]phenol | HCID 23111406 | 73.1% |
반응 단계
Production Example 30 was repeated except that 1-(4-benzyloxy-3-chlorophenyl)-4-(3-cyclohexylpropyl)piperazine was replaced with 1-(4-benzyloxy-3-fluorophenyl)-4-(3-phenylpropyl)-piperazine (394 mg). The resulting crude product was purified on TLC (developer, chloroform: methanol=10:1) to provide 2-fluoro-4-[4-(3-phenylpropyl)piperazin-1-yl]phenol (224 mg).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07449466B2 |
| 출처 데이터셋 | uspto-grants-2008_11 |
| ORD ID | ord-afb87b17d5614531bf0bf79ebf153926 |
| 출처 메모 | uspto-grants-2008_11 |