1-(4-Benzyloxy-3-chlorophenyl)-4-(3-cyclohexylpropyl)piperazine → HCID 23111403, compound

HRID 269902Notes

Reaction equation

HRID 269902 reaction equation
C(OC1C=CC(N2CCN(CCCC3CCCCC3)CC2)=CC=1[Cl:30])C1C=CC=CC=1.C([O:38][C:39]1[CH:44]=[CH:43][C:42]([N:45]2[CH2:50][CH2:49][N:48]([CH2:51][CH2:52][CH2:53][C:54]([C:56]3[CH:61]=[CH:60][C:59]([C:62]([CH3:65])([CH3:64])[CH3:63])=[CH:58][CH:57]=3)=[O:55])[CH2:47][CH2:46]2)=[CH:41][C:40]=1[F:66])C1C=CC=CC=1>>[ClH:30].[C:62]([C:59]1[CH:58]=[CH:57][C:56]([C:54](=[O:55])[CH2:53][CH2:52][CH2:51][N:48]2[CH2:47][CH2:46][N:45]([C:42]3[CH:43]=[CH:44][C:39]([OH:38])=[C:40]([F:66])[CH:41]=3)[CH2:50][CH2:49]2)=[CH:61][CH:60]=1)([CH3:65])([CH3:63])[CH3:64]

Participants

3

Reactant 2

HCID 231114081-(4-Benzyloxy-3-chlorophenyl)-4-(3-cyclohexylpropyl)piperazineHCID 23111450HCID 23111450, compound

Product 1

HCID 23111403HCID 23111403, compound

Procedure

Production Example 30 was repeated except that 1-(4-benzyloxy-3-chlorophenyl)-4-(3-cyclohexylpropyl)piperazine was replaced with 4-[4-(4-benzyloxy-3-fluorophenyl)piperazin-1-yl]-1-(4-tert-butylphenyl)-1-butanone (274 mg), to provide 1-(4-tert-butylphenyl)-4-[4-(3-fluoro-4-hydroxyphenyl)piperazin-1-yl]-1-butanone hydrochloride (191 mg).

Sources & evidence

ORD record
ord-d4f16bf9bc22433f9620dbd571bc1ac3
Source dataset
uspto-grants-2008_11
Patent number
US07449466B2

Reaction notes

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