Valeryl chloride → HCID 23111419, compound

HRID 269903Notes

Reaction equation

HRID 269903 reaction equation
Cl.Cl.C[O:4][C:5]1C=[CH:9][C:8](N2CCNCC2)=[CH:7][CH:6]=1.C(Cl)(=O)CC(C)C.[CH2:24]([O:31][C:32]1[CH:37]=[CH:36][C:35]([N:38]2[CH2:43][CH2:42][NH:41][CH2:40][CH2:39]2)=[CH:34][C:33]=1[F:44])[C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1.C(Cl)(=O)CCCC>>[CH2:24]([O:31][C:32]1[CH:37]=[CH:36][C:35]([N:38]2[CH2:43][CH2:42][N:41]([C:5](=[O:4])[CH2:6][CH2:7][CH2:8][CH3:9])[CH2:40][CH2:39]2)=[CH:34][C:33]=1[F:44])[C:25]1[CH:26]=[CH:27][CH:28]=[CH:29][CH:30]=1

Participants

5

Reactant 4

HCID 61186Valeryl chlorideHCID 66054Isovaleryl chlorideHCID 27237001-(4-Methoxyphenyl)-piperazine, dihydrochlorideHCID 231114831-(4-Benzyloxy-3-fluorophenyl)piperazine

Product 1

HCID 23111419HCID 23111419, compound

Procedure

Production Example 3 was repeated except that 1-(4-methoxyphenyl)-piperazine dihydrochloride and isovaleryl chloride were replaced with 1-(4-benzyloxy-3-fluorophenyl)piperazine (286 mg) and valeryl chloride (131 μL), respectively, to provide crude 4-(4-benzyloxy-3-fluorophenyl)-1-valerylpiperazine (367 mg).

Sources & evidence

ORD record
ord-212e4284e9914b80a3d974eec0df60b0
Source dataset
uspto-grants-2008_11
Patent number
US07449466B2

Reaction notes

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