1-(4-Methoxyphenyl)-4-phenethylpiperazine → HCID 23111465, compound

HRID 269904Notes

Reaction equation

HRID 269904 reaction equation
COC1C=CC(N2CCN(CCC3C=CC=CC=3)CC2)=CC=1.C([O:30][C:31]1[CH:36]=[CH:35][C:34]([N:37]2[CH2:42][CH2:41][N:40]([C:43](=[O:48])[CH2:44][CH2:45][CH2:46][CH3:47])[CH2:39][CH2:38]2)=[CH:33][C:32]=1[F:49])C1C=CC=CC=1>>[F:49][C:32]1[CH:33]=[C:34]([N:37]2[CH2:42][CH2:41][N:40]([C:43](=[O:48])[CH2:44][CH2:45][CH2:46][CH3:47])[CH2:39][CH2:38]2)[CH:35]=[CH:36][C:31]=1[OH:30]

Participants

3

Reactant 2

HCID 155270761-(4-Methoxyphenyl)-4-phenethylpiperazineHCID 23111419HCID 23111419, compound

Product 1

HCID 23111465HCID 23111465, compoundYield 22%

Procedure

Production Example 2 was repeated except that 1-(4-methoxyphenyl)-4-phenethylpiperazine was replaced with 4-(4-benzyloxy-3-fluorophenyl)-1-valerylpiperazine (367 mg). The resulting crude product was purified on TLC (developer, chloroform: methanol=12:1) to provide 4-(3-fluoro-4-hydroxyphenyl)-1-valerylpiperazine (61 mg).

Workup

  1. customThe resulting crude product was purified on TLC (developer, chloroform: methanol=12:1)

Sources & evidence

ORD record
ord-8c0e66ea39424142a18066b25da34865
Source dataset
uspto-grants-2008_11
Patent number
US07449466B2

Reaction notes

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