1-(4-Benzyloxy-3-chlorophenyl)-4-(3-cyclohexylpropyl)piperazine → HCID 23111493, compound

HRID 269905Notes

Reaction equation

HRID 269905 reaction equation
C(OC1C=CC(N2CCN(CCCC3CCCCC3)CC2)=CC=1[Cl:30])C1C=CC=CC=1.C([O:38][C:39]1[CH:44]=[CH:43][C:42]([N:45]2[CH2:50][CH2:49][NH:48][CH2:47][CH2:46]2)=[CH:41][C:40]=1[F:51])C1C=CC=CC=1>>[ClH:30].[F:51][C:40]1[CH:41]=[C:42]([N:45]2[CH2:46][CH2:47][NH:48][CH2:49][CH2:50]2)[CH:43]=[CH:44][C:39]=1[OH:38]

Participants

3

Reactant 2

HCID 231114081-(4-Benzyloxy-3-chlorophenyl)-4-(3-cyclohexylpropyl)piperazineHCID 231114831-(4-Benzyloxy-3-fluorophenyl)piperazine

Product 1

HCID 23111493HCID 23111493, compound

Procedure

Production Example 30 was repeated except that 1-(4-benzyloxy-3-chlorophenyl)-4-(3-cyclohexylpropyl)piperazine was replaced with 1-(4-benzyloxy-3-fluorophenyl)piperazine (300 mg), to provide 2-fluoro-4-(piperazin-1-yl)phenol hydrochloride (267 mg).

Sources & evidence

ORD record
ord-dc193bf3f58e4dd186dfab61bd8b2c29
Source dataset
uspto-grants-2008_11
Patent number
US07449466B2

Reaction notes

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