HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(4-Benzyloxy-3-chlorophenyl)-4-(3-cyclohexylpropyl)piperazine → HCID 23111440, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(4-Benzyloxy-3-chlorophenyl)-4-(3-cyclohexylpropyl)piperazine | HCID 23111408 | — |
| Reactant | HCID 23111441 | HCID 23111441 | — |
| Product | HCID 23111440 | HCID 23111440 | 57.2% |
Reaction Steps
Production Example 30 was repeated except that 1-(4-benzyloxy-3-chlorophenyl)-4-(3-cyclohexylpropyl)piperazine was replaced with N,N-diethyl-4-(4-benzyloxy-3-fluorophenyl)-1-piperazinecarboxamide (365 mg). The resulting crude product was purified on TLC (developer, chloroform:methanol=12:1) to provide N,N-diethyl-4-(3-fluoro-4-hydroxyphenyl)-1-piperazinecarboxamide (160 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07449466B2 |
| Source dataset | uspto-grants-2008_11 |
| ORD ID | ord-528358b61c6d4deba98dca266c929ed0 |
| Source note | uspto-grants-2008_11 |