HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Benzylpiperidine → 4-Benzyl-1-(2,5-difluoro-4-methoxyphenyl)piperidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Benzylpiperidine | HCID 31738 | — |
| Reactant | 1-Phenethylpiperazine | HCID 79214 | — |
| Reactant | 4-Bromo-1-methoxy-2-methylbenzene | HCID 608315 | — |
| Reactant | 4-Bromo-2,5-difluoroanisole | HCID 2724983 | — |
| Product | 4-Benzyl-1-(2,5-difluoro-4-methoxyphenyl)piperidine | HCID 23111488 | — |
Reaction Steps
Production Example 9 was repeated except that 5-bromo-2-methoxytoluene was replaced with 4-bromo-2,5-difluoroanisole (446 mg), and 1-phenethylpiperazine was replaced with 4-benzylpiperidine (2.30 mL). The resulting crude product was purified on silica gel column chromatography (eluent, hexane: ethyl acetate=4:1) to provide 4-benzyl-1-(2,5-difluoro-4-methoxyphenyl)piperidine (304 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07449466B2 |
| Source dataset | uspto-grants-2008_11 |
| ORD ID | ord-3987f2373a064c359b87bffb8d41cc42 |
| Source note | uspto-grants-2008_11 |