HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(4-Methoxyphenyl)-4-phenethylpiperazine → 4-(4-Benzylpiperidino)-2,5-difluorophenol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(4-Methoxyphenyl)-4-phenethylpiperazine | HCID 15527076 | — |
| Reactant | 4-Benzyl-1-(2,5-difluoro-4-methoxyphenyl)piperidine | HCID 23111488 | — |
| Product | 4-(4-Benzylpiperidino)-2,5-difluorophenol | HCID 23111480 | 48.1% |
Reaction Steps
Production Example 2 was repeated except that 1-(4-methoxyphenyl)-4-phenethylpiperazine was replaced with 4-benzyl-1-(2,5-difluoro-4-methoxyphenyl)piperidine (300 mg). The resulting crude product was purified on silica gel column chromatography (eluent, hexane: ethyl acetate=4:1) to provide 4-(4-benzylpiperidino)-2,5-difluorophenol (138 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07449466B2 |
| Source dataset | uspto-grants-2008_11 |
| ORD ID | ord-1b615a287fed4b68a80a9d1bf49b6e3c |
| Source note | uspto-grants-2008_11 |