HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Phenethylpiperazine → 4-(3-Cyclohexylpropyl)-1-(2,5-difluoro-4-methoxyphenyl)piperidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Phenethylpiperazine | HCID 79214 | — |
| Reactant | 4-Bromo-1-methoxy-2-methylbenzene | HCID 608315 | — |
| Reactant | 4-Bromo-2,5-difluoroanisole | HCID 2724983 | — |
| Reactant | 4-(3-Cyclohexylpropyl)-piperidine | HCID 23111496 | — |
| Product | 4-(3-Cyclohexylpropyl)-1-(2,5-difluoro-4-methoxyphenyl)piperidine | HCID 23111463 | 98.2% |
Reaction Steps
Production Example 9 was repeated except that 5-bromo-2-methoxytoluene and 1-phenethylpiperazine were replaced with 4-bromo-2,5-difluoroanisole (338 mg) and 4-(3-cyclohexylpropyl)-piperidine (953 mg), respectively. The resulting crude product was purified on silica gel column chromatography (eluent, hexane: ethyl acetate=3:1) to provide 4-(3-cyclohexylpropyl)-1-(2,5-difluoro-4-methoxyphenyl)piperidine (523 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07449466B2 |
| Source dataset | uspto-grants-2008_11 |
| ORD ID | ord-5b3ee35c5f6748ad81787f6e55408130 |
| Source note | uspto-grants-2008_11 |