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1-(4-Methoxyphenyl)-4-phenethylpiperazine → 4-[4-(3-Cyclohexylpropyl)piperidino]-2,5-difluorophenol
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1-(4-Methoxyphenyl)-4-phenethylpiperazine | HCID 15527076 | — |
| 反応物 | 4-(3-Cyclohexylpropyl)-1-(2,5-difluoro-4-methoxyphenyl)piperidine | HCID 23111463 | — |
| 生成物 | 4-[4-(3-Cyclohexylpropyl)piperidino]-2,5-difluorophenol | HCID 23111444 | 253.6% |
反応手順
Production Example 2 was repeated except that 1-(4-methoxyphenyl)-4-phenethylpiperazine was replaced with 4-(3-cyclohexylpropyl)-1-(2,5-difluoro-4-methoxyphenyl)piperidine (246 mg), to provide crude 4-[4-(3-cyclohexylpropyl)piperidino]-2,5-difluorophenol (599 mg).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07449466B2 |
| 出典データセット | uspto-grants-2008_11 |
| ORD ID | ord-df1ee3b037704b27a0d4791d3ad1df9b |
| 出典メモ | uspto-grants-2008_11 |