HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,4-Dioxa-8-azaspiro(4.5)decane → 8-(2,5-Difluoro-4-methoxyphenyl)-1,4-dioxa-8-azaspiro[4,5]decane
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,4-Dioxa-8-azaspiro(4.5)decane | HCID 67435 | — |
| Reactant | 1-Phenethylpiperazine | HCID 79214 | — |
| Reactant | 4-Bromo-1-methoxy-2-methylbenzene | HCID 608315 | — |
| Reactant | 4-Bromo-2,5-difluoroanisole | HCID 2724983 | — |
| Product | 8-(2,5-Difluoro-4-methoxyphenyl)-1,4-dioxa-8-azaspiro[4,5]decane | HCID 23111420 | 31.9% |
Reaction Steps
Production Example 9 was repeated except that 5-bromo-2-methoxytoluene and 1-phenethylpiperazine were replaced with 4-bromo-2,5-difluoroanisole (1.115 g) and 1,4-dioxa-8-azaspiro[4,5]-decane (859 mg), respectively. The resulting crude product was purified on silica gel column chromatography (eluent, hexane: ethyl acetate=3:1) to provide 8-(2,5-difluoro-4-methoxyphenyl)-1,4-dioxa-8-azaspiro[4,5]decane (455 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07449466B2 |
| Source dataset | uspto-grants-2008_11 |
| ORD ID | ord-f2ca42d4abda4f47bba3145d78b86179 |
| Source note | uspto-grants-2008_11 |