HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methoxymethyl-triphenylphosphonium chloride → HCID 67526767, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methoxymethyl-triphenylphosphonium chloride | HCID 2723798 | — |
| Reactant | Phenethyltriphenylphosphonium bromide | HCID 10863251 | — |
| Reactant | 1-(2,5-Difluoro-4-methoxyphenyl)piperidin-4-one | HCID 23111466 | — |
| Reactant | 1-(2,5-Difluoro-4-methoxyphenyl)-4-piperidinecarbaldehyde | HCID 23111501 | — |
| Product | HCID 67526767 | HCID 67526767 | 78.6% |
Reaction Steps
Production Example 74 was repeated except that methoxymethyltriphenylphosphonium chloride and 1-(2,5-difluoro-4-methoxyphenyl)piperidin-4-one were replaced with phenethyltri-phenylphosphonium bromide (133 mg) and 1-(2,5-difluoro-4-methoxyphenyl)-4-piperidinecarbaldehyde (35 mg), respectively, and the resulting crude product was purified on TLC (developer, hexane: ethyl acetate=10:1) to provide (Z)-1-(2,5-difluoro-4-methoxyphenyl)-4-(3-phenyl-1-propen-1-yl)piperidine (37 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07449466B2 |
| Source dataset | uspto-grants-2008_11 |
| ORD ID | ord-67f811637d1746b9803a3db98e54a5be |
| Source note | uspto-grants-2008_11 |