HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(4-Methoxyphenyl)-4-phenethylpiperazine → (Z)-2,5-difluoro-4-[4-(3-phenyl-1-propen-1-yl)-piperidino]phenol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(4-Methoxyphenyl)-4-phenethylpiperazine | HCID 15527076 | — |
| Reactant | (Z)-1-(2,5-difluoro-4-methoxyphenyl)-4-(3-phenyl-1-propen-1-yl)piperidine | HCID 67526767 | — |
| Product | (Z)-2,5-difluoro-4-[4-(3-phenyl-1-propen-1-yl)-piperidino]phenol | HCID 67526873 | 278% |
Reaction Steps
Production Example 2 was repeated except that 1-(4-methoxyphenyl)-4-phenethylpiperazine was replaced with (Z)-1-(2,5-difluoro-4-methoxyphenyl)-4-(3-phenyl-1-propen-1-yl)piperidine (18 mg), to provide crude (Z)-2,5-difluoro-4-[4-(3-phenyl-1-propen-1-yl)-piperidino]phenol (48 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07449466B2 |
| Source dataset | uspto-grants-2008_11 |
| ORD ID | ord-430da43c94b34da38552ee588e331b01 |
| Source note | uspto-grants-2008_11 |