HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phenethyl bromide → 1-(2-Cyclohexylethyl)-4-(2,5-difluoro-4-methoxyphenyl)piperazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phenethyl bromide | HCID 7666 | — |
| Reactant | 1-(4-Methoxyphenyl)-piperazine, dihydrochloride | HCID 2723700 | — |
| Reactant | 2-Cyclohexylethyl methylsulfonate | HCID 22723173 | — |
| Reactant | 1-(2,5-Difluoro-4-methoxyphenyl)piperazine | HCID 23111492 | — |
| Product | 1-(2-Cyclohexylethyl)-4-(2,5-difluoro-4-methoxyphenyl)piperazine | HCID 23111479 | — |
Reaction Steps
Production Example 1 was repeated except that 1-(4-methoxyphenyl)piperazine dihydrochloride and (2-bromoethyl)-benzene were replaced with 1-(2,5-difluoro-4-methoxyphenyl)-piperazine (342 mg) and 2-cyclohexylethyl methylsulfonate (309 mg), respectively, to provide crude 1-(2-cyclohexylethyl)-4-(2,5-difluoro-4-methoxyphenyl)piperazine (476 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07449466B2 |
| Source dataset | uspto-grants-2008_11 |
| ORD ID | ord-67875280920946beabd45c1e37fa0c34 |
| Source note | uspto-grants-2008_11 |