HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
1-(2-Cyclohexylethyl)-4-(2,5-difluoro-4-methoxyphenyl)piperazine → 4-[4-(2-Cyclohexylethyl)piperazin-1-yl]-2,5-difluorophenol
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 1-(2-Cyclohexylethyl)-4-(2,5-difluoro-4-methoxyphenyl)piperazine | HCID 23111479 | — |
| Edukt | 1-(4-Methoxy-3-methylphenyl)-4-phenethylpiperazine | HCID 23111510 | — |
| Produkt | 4-[4-(2-Cyclohexylethyl)piperazin-1-yl]-2,5-difluorophenol | HCID 23111460 | 36,3% |
Reaktionsschritte
Production Example 10 was repeated except that 1-(4-methoxy-3-methylphenyl)-4-phenethylpiperazine was replaced with 1-(2-cyclohexylethyl)-4-(2,5-difluoro-4-methoxyphenyl)-piperazine (250 mg). The resulting crude product was purified on TLC (developer, chloroform: methanol=13:1) to provide 4-[4-(2-cyclohexylethyl)piperazin-1-yl]-2,5-difluorophenol (87 mg).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US07449466B2 |
| Quelldatensatz | uspto-grants-2008_11 |
| ORD ID | ord-60e5a080e5344211a2f049a0081f27ba |
| Quellennotiz | uspto-grants-2008_11 |