HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 23111487, compound → 2,5-Difluoro-4-(4-phenethylpiperazin-1-yl)phenol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 23111487 | HCID 23111487 | — |
| Reactant | 1-(4-Methoxy-3-methylphenyl)-4-phenethylpiperazine | HCID 23111510 | — |
| Product | 2,5-Difluoro-4-(4-phenethylpiperazin-1-yl)phenol | HCID 23111504 | 85.9% |
Reaction Steps
Production Example 10 was repeated except that 1-(4-methoxy-3-methylphenyl)-4-phenethylpiperazine was replaced with 1-(2,5-difluoro-4-methoxyphenyl)-4-phenethylpiperazine (571 mg). The resulting crude product was purified on TLC (developer, chloroform: methanol=15:1) to provide 2,5-difluoro-4-(4-phenethylpiperazin-1-yl)phenol (470 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07449466B2 |
| Source dataset | uspto-grants-2008_11 |
| ORD ID | ord-d8917f011d794da78b50d579fe1f8e3d |
| Source note | uspto-grants-2008_11 |