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Phenethyl bromide → 1-(3-Cyclopentylpropyl)-4-(2,5-difluoro-4-methoxyphenyl)piperazine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Phenethyl bromide | HCID 7666 | — |
| 反応物 | 1-(4-Methoxyphenyl)-piperazine, dihydrochloride | HCID 2723700 | — |
| 反応物 | 3-Cyclopentylpropyl methanesulfonate | HCID 23111435 | — |
| 反応物 | 1-(2,5-Difluoro-4-methoxyphenyl)piperazine | HCID 23111492 | — |
| 生成物 | 1-(3-Cyclopentylpropyl)-4-(2,5-difluoro-4-methoxyphenyl)piperazine | HCID 23111395 | — |
反応手順
Production Example 1 was repeated except that 1-(4-methoxyphenyl)piperazine dihydrochloride and (2-bromoethyl)-benzene were replaced with 1-(2,5-difluoro-4-methoxyphenyl)-piperazine (342 mg) and 3-cyclopentylpropyl methylsulfonate (309 mg), respectively, to provide crude 1-(3-cyclopentylpropyl)-4-(2,5-difluoro-4-methoxyphenyl)piperazine (486 mg).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07449466B2 |
| 出典データセット | uspto-grants-2008_11 |
| ORD ID | ord-4354032514ac42e6a155f6e50c6a0ce8 |
| 出典メモ | uspto-grants-2008_11 |