HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(3-Cyclopentylpropyl)-4-(2,5-difluoro-4-methoxyphenyl)piperazine → 4-[4-(3-Cyclopentylpropyl)piperazin-1-yl]-2,5-difluorophenol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(3-Cyclopentylpropyl)-4-(2,5-difluoro-4-methoxyphenyl)piperazine | HCID 23111395 | — |
| Reactant | 1-(4-Methoxy-3-methylphenyl)-4-phenethylpiperazine | HCID 23111510 | — |
| Product | 4-[4-(3-Cyclopentylpropyl)piperazin-1-yl]-2,5-difluorophenol | HCID 23111499 | 34.6% |
Reaction Steps
Production Example 10 was repeated except that 1-(4-methoxy-3-methylphenyl)-4-phenethylpiperazine was replaced with 1-(3-cyclopentylpropyl)-4-(2,5-difluoro-4-methoxyphenyl)-piperazine (250 mg). The resulting crude product was purified on TLC (developer, chloroform: methanol=16:1) to provide 4-[4-(3-cyclopentylpropyl)piperazin-1-yl]-2,5-difluorophenol (83 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07449466B2 |
| Source dataset | uspto-grants-2008_11 |
| ORD ID | ord-e66ff045500e4e16b60153ab1df8c51e |
| Source note | uspto-grants-2008_11 |