化工社化工社 化学情報印刷レポート · 研究参考用
1-Bromooctane → 1-(3-Cyclohexylpropyl)-4-(2,5-difluoro-4-methoxyphenyl)piperazine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1-Bromooctane | HCID 8140 | — |
| 反応物 | 3-Cyclohexylpropyl methanesulfonate | HCID 23111443 | — |
| 反応物 | 1-(4-Benzyloxy-3-fluorophenyl)piperazine | HCID 23111483 | — |
| 反応物 | 1-(2,5-Difluoro-4-methoxyphenyl)piperazine | HCID 23111492 | — |
| 生成物 | 1-(3-Cyclohexylpropyl)-4-(2,5-difluoro-4-methoxyphenyl)piperazine | HCID 23111426 | 97.6% |
反応手順
Production Example 38 was repeated except that 1-(4-benzyloxy-3-fluorophenyl)piperazine and n-octyl bromide were replaced with 1-(2,5-difluoro-4-methoxyphenyl)piperazine (5.72 g) and 3-cyclohexylpropyl methanesulfonate (5.52 g), to provide crude 1-(3-cyclohexylpropyl)-4-(2,5-difluoro-4-methoxyphenyl)piperazine (8.618 g).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07449466B2 |
| 出典データセット | uspto-grants-2008_11 |
| ORD ID | ord-1b0415f35aed4884926bf0f098b46b1e |
| 出典メモ | uspto-grants-2008_11 |