化工社化工社 化学情報印刷レポート · 研究参考用
1-Bromooctane → 3-[4-(2,5-Difluoro-4-methoxyphenyl)piperazin-1-yl]-1-phenylpropan-1-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1-Bromooctane | HCID 8140 | — |
| 反応物 | 3-Chloropropiophenone | HCID 70295 | — |
| 反応物 | 1-(4-Benzyloxy-3-fluorophenyl)piperazine | HCID 23111483 | — |
| 反応物 | 1-(2,5-Difluoro-4-methoxyphenyl)piperazine | HCID 23111492 | — |
| 生成物 | 3-[4-(2,5-Difluoro-4-methoxyphenyl)piperazin-1-yl]-1-phenylpropan-1-one | HCID 23111425 | 101.4% |
反応手順
Production Example 38 was repeated except that 1-(4-benzyloxy-3-fluorophenyl)piperazine and n-octyl bromide were replaced with 1-(2,5-difluoro-4-methoxyphenyl)piperazine (228 mg) and 3-chloro-1-phenylpropan-1-one (169 mg), to provide crude 3-[4-(2,5-difluoro-4-methoxyphenyl)piperazin-1-yl]-1-phenylpropan-1-one (365 mg).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07449466B2 |
| 出典データセット | uspto-grants-2008_11 |
| ORD ID | ord-a08f6455f53f4a40baf63ef1ca5caf58 |
| 出典メモ | uspto-grants-2008_11 |