HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(4-Methoxyphenyl)-4-phenethylpiperazine → 3-[4-(2,5-Difluoro-4-hydroxyphenyl)-piperazin-1-yl]-1-phenylpropan-1-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(4-Methoxyphenyl)-4-phenethylpiperazine | HCID 15527076 | — |
| Reactant | 3-[4-(2,5-Difluoro-4-methoxyphenyl)piperazin-1-yl]-1-phenylpropan-1-one | HCID 23111425 | — |
| Product | 3-[4-(2,5-Difluoro-4-hydroxyphenyl)-piperazin-1-yl]-1-phenylpropan-1-one | HCID 23111469 | 101% |
Reaction Steps
Production Example 2 was repeated except that 1-(4-methoxyphenyl)-4-phenethylpiperazine was replaced with 3-[4-(2,5-difluoro-4-methoxyphenyl)piperazin-1-yl]-1-phenylpropan-1-one (344 mg), to provide crude 3-[4-(2,5-difluoro-4-hydroxyphenyl)-piperazin-1-yl]-1-phenylpropan-1-one (334 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07449466B2 |
| Source dataset | uspto-grants-2008_11 |
| ORD ID | ord-b651fc0d119f4a1c97b178189abc66f9 |
| Source note | uspto-grants-2008_11 |