HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Bromooctane → 1-(4-Tert-butylphenyl)-4-[4-(2,5-difluoro-4-methoxyphenyl)piperazin-1-yl]butan-1-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Bromooctane | HCID 8140 | — |
| Reactant | 4'-tert-Butyl-4-chlorobutyrophenone | HCID 2723694 | — |
| Reactant | 1-(4-Benzyloxy-3-fluorophenyl)piperazine | HCID 23111483 | — |
| Reactant | 1-(2,5-Difluoro-4-methoxyphenyl)piperazine | HCID 23111492 | — |
| Product | 1-(4-Tert-butylphenyl)-4-[4-(2,5-difluoro-4-methoxyphenyl)piperazin-1-yl]butan-1-one | HCID 23111410 | 79.8% |
Reaction Steps
Production Example 38 was repeated except that 1-(4-benzyloxy-3-fluorophenyl)piperazine and n-octyl bromide were replaced with 1-(2,5-difluoro-4-methoxyphenyl)piperazine (228 mg) and 1-(4-tert-butylphenyl)-4-chlorobutan-1-one (239 mg). The resulting crude product was purified on silica gel column chromatography (eluent, ethyl acetate) to provide 1-(4-tert-butylphenyl)-4-[4-(2,5-difluoro-4-methoxyphenyl)piperazin-1-yl]-butan-1-one (343 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07449466B2 |
| Source dataset | uspto-grants-2008_11 |
| ORD ID | ord-3370eef1c60f41abbe0b2300cba1bfbe |
| Source note | uspto-grants-2008_11 |