1-(4-Methoxyphenyl)-4-phenethylpiperazine → HCID 23111448, compound

HRID 269936Notes

Reaction equation

HRID 269936 reaction equation
COC1C=CC(N2CCN(CCC3C=CC=CC=3)CC2)=CC=1.[C:23]([N:34]1[CH2:39][CH2:38][N:37]([C:40]2[CH:45]=[C:44]([F:46])[C:43]([O:47]C)=[CH:42][C:41]=2[F:49])[CH2:36][CH2:35]1)(=[O:33])[CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH3:32]>>[C:23]([N:34]1[CH2:35][CH2:36][N:37]([C:40]2[CH:45]=[C:44]([F:46])[C:43]([OH:47])=[CH:42][C:41]=2[F:49])[CH2:38][CH2:39]1)(=[O:33])[CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH3:32]

Participants

3

Reactant 2

HCID 155270761-(4-Methoxyphenyl)-4-phenethylpiperazineHCID 23111486HCID 23111486, compound

Product 1

HCID 23111448HCID 23111448, compoundYield 75%

Procedure

Production Example 2 was repeated except that 1-(4-methoxyphenyl)-4-phenethylpiperazine was replaced with 1-decanoyl-4-(2,5-difluoro-4-methoxyphenyl)piperazine (371 mg). The resulting crude product was purified on TLC (developer, chloroform: methanol=19:1) to provide 1-decanoyl-4-(2,5-difluoro-4-hydroxyphenyl)piperazine (268 mg).

Workup

  1. customThe resulting crude product was purified on TLC (developer, chloroform: methanol=19:1)

Sources & evidence

ORD record
ord-1885f6000ee04054aab18b53d99318e0
Source dataset
uspto-grants-2008_11
Patent number
US07449466B2

Reaction notes

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