HuagongsheHuagongshe Chemistry Print Report · For research reference only
Isovaleryl chloride → 1-(4-Tert-butylbenzoyl)-4-(2,5-difluoro-4-methoxyphenyl)piperazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Isovaleryl chloride | HCID 66054 | — |
| Reactant | 4-tert-Butylbenzoyl chloride | HCID 74372 | — |
| Reactant | 1-(4-Methoxyphenyl)-piperazine, dihydrochloride | HCID 2723700 | — |
| Reactant | 1-(2,5-Difluoro-4-methoxyphenyl)piperazine | HCID 23111492 | — |
| Product | 1-(4-Tert-butylbenzoyl)-4-(2,5-difluoro-4-methoxyphenyl)piperazine | HCID 23111512 | — |
Reaction Steps
Production Example 3 was repeated except that 1-(4-methoxyphenyl)piperazine dihydrochloride and isovaleryl chloride were replaced with 1-(2,5-difluoro-4-methoxyphenyl)-piperazine (228 mg) and 4-tert-butylbenzoyl chloride (234 μL), respectively, to provide crude 1-(4-tert-butylbenzoyl)-4-(2,5-difluoro-4-methoxyphenyl)piperazine (433 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07449466B2 |
| Source dataset | uspto-grants-2008_11 |
| ORD ID | ord-f80d1e031ed8481cba4fc3443583be1d |
| Source note | uspto-grants-2008_11 |