HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(4-Methoxyphenyl)-4-phenethylpiperazine → 1-(4-Tert-butylbenzoyl)-4-(2,5-difluoro-4-hydroxyphenyl)piperazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(4-Methoxyphenyl)-4-phenethylpiperazine | HCID 15527076 | — |
| Reactant | 1-(4-Tert-butylbenzoyl)-4-(2,5-difluoro-4-methoxyphenyl)piperazine | HCID 23111512 | — |
| Product | 1-(4-Tert-butylbenzoyl)-4-(2,5-difluoro-4-hydroxyphenyl)piperazine | HCID 23111396 | 67.6% |
Reaction Steps
Production Example 2 was repeated except that 1-(4-methoxyphenyl)-4-phenethylpiperazine was replaced with 1-(4-tert-butylbenzoyl)-4-(2,5-difluoro-4-methoxyphenyl)piperazine (433 mg), to provide crude 1-(4-tert-butylbenzoyl)-4-(2,5-difluoro-4-hydroxyphenyl)piperazine (282 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07449466B2 |
| Source dataset | uspto-grants-2008_11 |
| ORD ID | ord-a0c2c73c284b4545af908ac78ebb613f |
| Source note | uspto-grants-2008_11 |