HuagongsheHuagongshe Chemistry Print Report · For research reference only
Piperazine → 1-(2,5-Difluoro-4-methoxyphenyl)piperazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Piperazine | HCID 4837 | — |
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | 4-Bromo-1-methoxy-2-methylbenzene | HCID 608315 | — |
| Reactant | 4-Bromo-2,5-difluoroanisole | HCID 2724983 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 1-(2,5-Difluoro-4-methoxyphenyl)piperazine | HCID 23111492 | 27.9% |
Reaction Steps
Production Example 9 was repeated except that 5-bromo-2-methoxytoluene, 1-(2-phenethyl)piperazine and ethyl acetate (extraction solvent) were replaced with 4-bromo-2,5-difluoroanisole (6.742 g), piperazine (12.404 g) and toluene (extraction solvent), respectively, to provide crude 1-(2,5-difluoro-4-methoxyphenyl)-piperazine (1.926 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07449466B2 |
| Source dataset | uspto-grants-2008_11 |
| ORD ID | ord-e0a9d9d39c0f4a12a83b8b7c3cdc8e94 |
| Source note | uspto-grants-2008_11 |