化工社化工社 化学情報印刷レポート · 研究参考用
Isovaleryl chloride → 4-(2,5-Difluoro-4-methoxyphenyl)-1-(octylsulfonyl)piperazine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Isovaleryl chloride | HCID 66054 | — |
| 反応物 | 1-Octanesulfonyl chloride | HCID 82261 | — |
| 反応物 | 1-(4-Methoxyphenyl)-piperazine, dihydrochloride | HCID 2723700 | — |
| 反応物 | 1-(2,5-Difluoro-4-methoxyphenyl)piperazine | HCID 23111492 | — |
| 生成物 | 4-(2,5-Difluoro-4-methoxyphenyl)-1-(octylsulfonyl)piperazine | HCID 23111477 | — |
反応手順
Production Example 3 was repeated except that 1-(4-methoxyphenyl)piperazine dihydrochloride and isovaleryl chloride were replaced with 1-(2,5-difluoro-4-methoxyphenyl)-piperazine (456 mg) and 1-octanesulfonyl chloride (470 μL), respectively, to provide crude 4-(2,5-difluoro-4-methoxyphenyl)-1-(octylsulfonyl)piperazine (681 mg).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07449466B2 |
| 出典データセット | uspto-grants-2008_11 |
| ORD ID | ord-990d7e1f09e3475ba7413660505d1012 |
| 出典メモ | uspto-grants-2008_11 |